Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate
- Name Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate
- CAS 179688-27-8
- Purity 99%
Product Details
Quality products?make an important contribution to long-term revenue and profitability. Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate 179688-27-8 with purity >99% Low price in stock
1.What is the Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate ?
2-Amino-4,5-bis(2-methoxyethoxy)benzoic Acid Ethyl Ester is an intermediate in the synthesis of Erlotinib (E625000, HCl); a selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and antineoplastic agent.
-
-
3943-89-3
Ethyl protocatechuate
-
-
179688-27-8
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
3
steps
1: potassium carbonate; tetrabutylammonium iodide / acetone / 120 h / Heating
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2
*H2
O / methanol / 20 °C / 2585.74 Torr
With
hydrogen; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid;
platinum(IV) oxide;
In
methanol; acetone;
|
|
|
Multi-step reaction
with
3
steps
1: potassium carbonate; tetrabutylammonium iodide / acetone
2: acetic acid; nitric acid / 24 h / 20 °C
3: hydrogen / PtO2
*H2
O / methanol / 20 °C / 2585.74 Torr
With
hydrogen; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid;
platinum(IV) oxide;
In
methanol; acetone;
|
|
|
Multi-step reaction
with
3
steps
1: 68 percent / potassium carbonate; tetrabutylammonium iodide / acetone / 72 h / Heating
2: nitric acid; trifluoroacetic acid / CH2
Cl2
/ 20 °C
3: 94 percent / hydrogen / palladium on activated carbon / methanol
With
hydrogen; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; acetone;
|
|
|
Multi-step reaction
with
3
steps
1: potassium carbonate; tetrabutylammomium bromide / acetonitrile
2: acetic acid; nitric acid / 0 °C
3: hydrogen; palladium on activated charcoal / methanol
With
palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; nitric acid; potassium carbonate; acetic acid;
In
methanol; acetonitrile;
|
|
|
Multi-step reaction
with
3
steps
1: potassium carbonate; tetrabutylammomium bromide / acetonitrile / Reflux
2: nitric acid / acetic acid / 0 °C
3: hydrogen; palladium on activated charcoal / methanol / 40 °C
With
palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; nitric acid; potassium carbonate;
In
methanol; acetic acid; acetonitrile;
|
|
|
Multi-step reaction
with
3
steps
1.1: ammonia; carbon dioxide / 0.5 h / 50 °C
2.1: acetic acid; nitric acid; sulfuric acid / 10 - 45 °C
3.1: palladium 10% on activated carbon / ethanol / 0.17 h / Autoclave
3.2: 60 °C / 3750.38 - 4500.45 Torr / Autoclave
With
carbon dioxide; sulfuric acid; palladium 10% on activated carbon; ammonia; nitric acid; acetic acid;
In
ethanol;
|
-
-
183322-16-9
3,4-bis(2-methoxyethoxy)benzoic acid ethyl ester
-
-
179688-27-8
ethyl 2-amino-4,5-bis(2-methoxyethoxy)-benzoate
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: acetic acid; nitric acid / 24 h / 20 °C
2: hydrogen / PtO2
*H2
O / methanol / 20 °C / 2585.74 Torr
With
hydrogen; nitric acid; acetic acid;
platinum(IV) oxide;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: nitric acid; trifluoroacetic acid / CH2
Cl2
/ 20 °C
2: 94 percent / hydrogen / palladium on activated carbon / methanol
With
hydrogen; nitric acid; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid; nitric acid / acetic acid / 15 - 35 °C
2: hydrogen; platinum on carbon / methanol / 20 - 40 °C / 760.05 Torr
With
sulfuric acid; platinum on carbon; hydrogen; nitric acid;
In
methanol; acetic acid;
|
|
|
Multi-step reaction
with
2
steps
1: acetic acid; nitric acid / 0 °C
2: hydrogen; palladium on activated charcoal / methanol
With
palladium on activated charcoal; hydrogen; nitric acid; acetic acid;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: acetic acid; sulfuric acid; nitric acid / 18 h / 20 °C
2: nickel; hydrogen / ethanol / 20 h / 40 °C
With
sulfuric acid; hydrogen; nitric acid; nickel; acetic acid;
In
ethanol;
|
|
|
Multi-step reaction
with
2
steps
1: sulfuric acid; nitric acid / dichloromethane / 2 h / 5 °C / Green chemistry
2: ethanol; sodium tetrahydroborate / 4 h / 30 - 40 °C / Green chemistry
With
sodium tetrahydroborate; ethanol; sulfuric acid; nitric acid;
In
dichloromethane;
|
|
|
Multi-step reaction
with
2
steps
1: nitric acid / acetic acid / 0 °C
2: hydrogen; palladium on activated charcoal / methanol / 40 °C
With
palladium on activated charcoal; hydrogen; nitric acid;
In
methanol; acetic acid;
|
|
|
Multi-step reaction
with
2
steps
1: nitric acid; sulfuric acid; acetic acid / 0.02 h / 60 °C
2: hydrogen; 10% Pt/activated carbon / methanol / 0.01 h / 90 °C / 11251.1 Torr
With
sulfuric acid; 10% Pt/activated carbon; hydrogen; nitric acid; acetic acid;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1: nitric acid; acetic acid / 24.5 h / 0 - 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 12 h
With
palladium 10% on activated carbon; hydrogen; nitric acid; acetic acid;
In
methanol;
|
|
|
Multi-step reaction
with
2
steps
1.1: acetic acid; nitric acid; sulfuric acid / 10 - 45 °C
2.1: palladium 10% on activated carbon / ethanol / 0.17 h / Autoclave
2.2: 60 °C / 3750.38 - 4500.45 Torr / Autoclave
With
sulfuric acid; palladium 10% on activated carbon; nitric acid; acetic acid;
In
ethanol;
|
2.What is the CAS number for Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate ?
The CAS number of Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate is 179688-27-8.
More information of Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate 179688-27-8 are:
|
CAS?Number |
179688-27-8 |
|
Density |
1.148 g/cm3 |
|
Boiling Point |
456.4 °C at 760 mmHg |
|
Flash Point |
183.9 °C |
|
Vapor Pressure |
1.62E-08mmHg at 25°C |
|
Refractive Index |
1.514 |
|
HS CODE |
2922509090 |
|
PSA |
89.24000 |
|
LogP |
2.07710 |
|
Pka |
2.52±0.10(Predicted) |
3.What are another words for Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate ?
Synonyms?for?Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate 179688-27-8:2-Amino-4,5-bis(2-methoxyethoxy)benzoicacid ethyl ester;4,5-Bis(2-methoxyethoxy)anthranilic acid ethyl ester;Ethyl2-amino-4,5-bis(2-methoxyethoxy)benzoate;
4.What is the molecular formula of Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate?
The chemical formula of ?Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate is?C15H23NO6 which containing 15 Carbon atoms,23 Hydrogen atoms,1 Nitrogen atoms and 6 Oxygen atoms,and the molecular weight of??Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate?is 313.351.
5.What is Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate (179688-27-8) used for?
Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate, also known as 2-Amino-4,5-bis(2-methoxyethoxy)benzoic Acid Ethyl Ester, is an organic compound that serves as an intermediate in the synthesis of Erlotinib, a selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and antineoplastic agent.
InChI:InChI=1/C15H23NO6/c1-4-20-15(17)11-9-13(21-7-5-18-2)14(10-12(11)16)22-8-6-19-3/h9-10H,4-8,16H2,1-3H3
Relevant articles related to Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate:
|
Article |
Source |
|
Synthesis and evaluation of novel 18F-labeled quinazoline derivatives with low lipophilicity for tumor PET imaging |
Chong, Yan,Chang, Jin,Zhao, Wenwen,He, Yong,Li, Yuqiao,Zhang, Huabei,Qi, Chuanmin , p. 42 - 53 (2018/02/06) |
|
Preparation method of erlotinib intermediate |
- , (2018/03/01) |
6.Buy Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate with the best price .
KABILY CHEMICAL CO.,LTD.(expird) is a quality supplier of Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate 179688-27-8.
