Tenofovir Alafenamide Fumarate
- Name Tenofovir Alafenamide Fumarate
- CAS 1392275-56-7
- Purity 99%
Product Details
Quality products?make an important contribution to long-term revenue and profitability. Manufacturer supply high quality Tenofovir Alafenamide Fumarate 1392275-56-7 with GMP standards
1.What is the Tenofovir Alafenamide Fumarate ?
Tenofovir alafenamide hemifumarate is a newer, more effective prodrug used in combination with FTC that has recently been approved for the prevention of HIV transmission through the rectum. It is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.
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147127-20-6
tenofovir
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1392275-56-7
tenofovir alafenamide hemifumarate
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
3
steps
1.1: dmap; triethylamine / 1-methyl-pyrrolidin-2-one; cyclohexane / 40 h / 80 °C
2.1: thionyl chloride; N,N-dimethyl-formamide / toluene; acetonitrile / 26.25 h / 20 - 70 °C
3.1: chloro-trimethyl-silane / dichloromethane / 1 h / 20 °C
3.2: 5 h / -25 - 3 °C
3.3: Reflux
With
dmap; chloro-trimethyl-silane; thionyl chloride; triethylamine; N,N-dimethyl-formamide;
In
1-methyl-pyrrolidin-2-one; dichloromethane; cyclohexane; toluene; acetonitrile;
|
|
|
Multi-step reaction
with
4
steps
1.1: dmap; triethylamine / 1-methyl-pyrrolidin-2-one; cyclohexane / 40 h / 80 °C
2.1: thionyl chloride; N,N-dimethyl-formamide / toluene; acetonitrile / 26.25 h / 20 - 70 °C
3.1: chloro-trimethyl-silane / dichloromethane / 1 h / 20 °C
3.2: 5 h / -25 - 3 °C
3.3: 55 °C
4.1: dichloromethane; water / 20 °C
4.2: 65 °C
With
dmap; chloro-trimethyl-silane; thionyl chloride; triethylamine; N,N-dimethyl-formamide;
In
1-methyl-pyrrolidin-2-one; dichloromethane; cyclohexane; water; toluene; acetonitrile;
|
|
|
Multi-step reaction
with
3
steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / water / 48 h / 80 - 90 °C
2: triethylamine / acetonitrile / 18 h / Reflux
3: acetonitrile / 70 - 75 °C
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
water; acetonitrile;
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110-17-8,26099-09-2
(2E)-but-2-enedioic acid
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379270-37-8,2053424-88-5,379270-36-7
(S)-isopropyl-2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate
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1392275-56-7
(S)-isopropyl-2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumarate
| Conditions | Yield |
|---|---|
|
In
acetonitrile;
at 55 ℃;
for 2h;
|
92%
|
|
In
acetonitrile;
at 20 - 70 ℃;
for 6h;
Temperature;
|
88%
|
|
In
acetonitrile;
at 75 - 78 ℃;
|
84.8%
|
|
In
acetonitrile;
at 0 - 73 ℃;
for 5.5h;
Large scale;
|
0.95 kg
|
|
In
acetonitrile;
at -5 - 75 ℃;
for 2.5h;
|
118 mg
|
|
In
dichloromethane; acetonitrile;
at 0 - 75 ℃;
|
|
|
In
1,4-dioxane;
at 25 - 30 ℃;
for 4h;
Inert atmosphere;
|
8 g
|
|
In
acetone;
at 50 - 60 ℃;
Concentration;
Solvent;
Temperature;
|
22 g
|
|
In
isopropyl alcohol;
for 0.5h;
Inert atmosphere;
Reflux;
|
|
|
In
acetonitrile;
for 24h;
Solvent;
|
2.What is the CAS number for Tenofovir Alafenamide Fumarate ?
The CAS number of Tenofovir Alafenamide Fumarate is 1392275-56-7.
More information of Tenofovir Alafenamide Fumarate 1392275-56-7 are:
|
CAS?Number |
1392275-56-7 |
|
PSA |
381.18000 |
|
LogP |
7.60180 |
3.What are another words for Tenofovir Alafenamide Fumarate ?
Synonyms?for?Tenofovir Alafenamide Fumarate 1392275-56-7:L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);GS-7340 (hemifumarate);(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1);(R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate;N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
4.What is the molecular formula of Tenofovir Alafenamide Fumarate?
The chemical formula of ?Tenofovir Alafenamide Fumarate is?C4 H4 O4 *C21 H29 N6 O5 P which containing 25 Carbon atoms,33 Hydrogen atoms,6 Oxygen atoms,6 Nitrogen atoms and 1 Phosphorus atoms,and the molecular weight of??Tenofovir Alafenamide Fumarate?is 592.546.
5.What is Tenofovir Alafenamide Fumarate (1392275-56-7) used for?
Tenofovir alafenamide hemifumarate is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
Relevant articles related to Tenofovir Alafenamide Fumarate:
|
Article |
Source |
|
Efficient synthesis and resolution of tenofovir alafenamide |
Gan, Yongjun,Ran, Kerui,Xie, Hongmeng,Yang, Bin , p. 10 - 14 (2018) |
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CRYSTAL FORM OF TENOFOVIR ALAFENAMIDE SALT, PREPARATION METHOD AND USE THEREOF |
- Paragraph 0039; 0040; 0041; 0042; 0043; 0044; 0045-0053, (2019/04/18) |
6.Buy Tenofovir Alafenamide Fumarate with the best price .
KABILY CHEMICAL CO.,LTD.(expird) is a quality supplier of Tenofovir Alafenamide Fumarate. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Tenofovir Alafenamide Fumarate 1392275-56-7.
